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Dose, Safety, and
Efficacy of Rhenium
Dose, Safety, and
Efficacy of Rhenium
The purpose of the ReSPECT™ Clinical Trial is to assess the safety, tolerability, and distribution of a new medication, Rhenium-186 NanoLiposome (186RNL), in adults with recurrent or progressive malignant glioma after standard surgical, radiation, and/or chemotherapy treatment. ReSPECT™ is supported by the U.S. National Institutes of Health / National Cancer Institute.
NATIONAL TRIAL REFERENCE NUMBER
When speaking with your physician, please have the national trial reference number available.
Patients Treated to Date
- All patients who enroll in the trial will receive medication while on the study.
- All patients will receive a single treatment of Rhenium-186 NanoLiposome (186RNL).
- Phase 1: A Phase 1 study of a new medication is usually the first that involves human volunteers who have the disease or condition the investigational medicine is designed to treat. The primary objective of Phase 1 studies is to identify the highest dose of the new medication that can be safely given without serious side effects.
- Phase 2: If a new medication is found to be reasonably safe in a Phase 1 study, it can then be evaluated in a Phase 2 study to determine if it works. Doctors will assess whether the new medication provides a specific benefit or response, such as tumor shrinkage, improved quality of life, or longer patient survival.
- Actual Study Start: June 3, 2015
- Estimated Primary Completion: January 2025 (the date that the last participant in a clinical study was examined or received an intervention and that data for the primary outcome measure were collected)
- Estimated Study Completion: January 2025 (the date on which the last participant in a clinical study was examined or received an intervention/treatment to collect final data for the primary outcome measures, secondary outcome measures, and adverse events, that is, the last participant’s last visit).
Only a qualified healthcare professional can determine whether or not you are eligible to participate in a clinical trial. However, this information may be beneficial in initiating a conversation with your physician. Patient reimbursement of up to $599 for time and travel is available. Healthy volunteers are not needed.
Recurrent or Progressive Malignant Glioma
Adults, 18 Years and Older
Able to undergo a MRI scan
Have not taken Avastin (bevacizumab)
Andrew Brenner, M.D., Ph.D.
UT Health San Antonio
Mays Cancer Center
SPECIALTIES: MEDICAL ONCOLOGY, INTERNAL MEDICINE
A specialist in both breast cancer and malignancies of the brain and spinal cord, Andrew Brenner, M.D., Ph.D., not only focuses on clinical management, but also on the development of novel therapies to treat breast cancers and central nervous system tumors.
A graduate of Texas A&M University, he earned his bachelor’s degree in biochemistry and went on to earn his doctorate in biological science and tumor biology at The University of Texas M.D. Anderson Cancer Center – Science Park. His doctoral thesis focused on the role of the cyclin dependent kinase inhibitor p16INK4a in mammary tumorigenesis and immortilization. Dr. Brenner’s current interests have transitioned from cell cycle to the effect of hypoxia on chemokines and escape from antiangiogenics and the role of obesity in promoting breast tumorigenesis.
Dr. Brenner received his medical degree from the Texas Tech University Health Science Center and completed a residency in internal medicine at Scott and White Hospital in Lubbock. He completed his fellowship in hematology and medical oncology at the UT Health San Antonio.
Toral Patel, M.D.
UT Southwestern Medical Center
Peter O’Donnell Jr. Brain Institute
SPECIALTIES: NEUROLOGICAL SURGERY, SKULL BASE TUMORS, NEUROLOGICAL DISORDERS
Toral Patel, M.D., is an Assistant Professor in UT Southwestern Medical Center’s nationally ranked Department of Neurological Surgery, where she specializes in brain tumor surgery.
Dr. Patel received her undergraduate degree in biomedical engineering from Johns Hopkins University and earned her medical degree at UT Southwestern Medical School. She completed an internship in general surgery at Yale-New Haven Hospital, followed by a residency in neurological surgery, serving as Chief Resident. She then received advanced training in neurosurgical oncology through a fellowship at Memorial Sloan Kettering Cancer Center before returning to UT Southwestern as a faculty member in 2014.
Dr. Patel’s research has garnered numerous awards, including the William F. Collins Resident Research Award, a Seed Grant from the American Medical Association, the UT Southwestern Medical Student Summer Research Award, the Louis E. Goodman Award, and the Johns Hopkins University Department of Biomedical Engineering Undergraduate Research Award. She currently holds a patent titled “Highly penetrative nanocarriers for treatment of CNS disease” for her research into how nanoparticles can be used to carry drugs directly to the site of brain tumors.
Dr. Patel is a member of the Society for Neuro-Oncology, the American Medical Association, the American College of Surgeons, the Congress of Neurological Surgeons, and the American Association of Neurological Surgeons.
She was included in D Magazine‘s Best Doctors list for 2018.
Jeffrey Weinberg, M.D.
UT MD Anderson Cancer Center
Anne C. Brooks Brain and Spine Center
SPECIALTIES: PRIMARY AND METASTATIC BRAIN TUMORS, SPINAL CORD TUMORS, STEREOTACTIC RADIOSURGERY
Dr. Jeffrey Weinberg is currently a Professor of Neurosurgery, Deputy Chair and Vice-Chair of Clinical Operations in The Department of Neurosurgery at The University of Texas MD Anderson Cancer Center in Houston, Texas. He is also the Director of the Intraoperative MRI Program.
Dr. Weinberg is a leader in the field of the Neurosurgical Oncology with particular knowledge about intraoperative MRI and technical expertise in surgical management of primary and metastatic brain tumors, spinal cord tumors and stereotactic radiosurgery. He has received various honors which include Excellence in Research Mentorship from the University of Texas Center for Biomedical Engineering, Houston, TX; the Excellence in Teaching Award from the University of Texas Center for Biomedical Engineering for three consecutive years, Top Doctor’s Designation by Castle Connolly and US News and World Report and most recently the MD Anderson Physician Referral Service Sam Hassenbusch Leadership and Institutional Service Award.
Dr. Weinberg is the Chair of the Peri-operative Value Analysis Team; President of the Intraoperative Imaging Society; past President of the Texas Association of Neurological Surgeons; Website Chair for the Joint Tumor Section of the AANS and CNS.
He has published more than 100 manuscripts in peer-reviewed journals and has authored 8 book chapters.
There are currently 3 clinical trial locations in the United States that are actively screening and enrolling patients.
Please visit this website regularly for updates as new locations are added.
UT Health Science Center
UT Southwestern Medical Center
UT MD Anderson Cancer Center
What Can You Do Next?
Participating in a clinical trial is an important decision. If you believe this clinical trial might be a good fit and are interested in participating, please take the next step to see if you are eligible.
Discuss With Your Physician
Anyone participating in a clinical trial should know as much as possible about what is being studied, what risks are involved and what potential benefits may be gained before deciding to enroll. If you are interested in participating in a clinical trial, please talk to your physician first.
Print, save, or email this page to your physician to discuss at your next visit.
Be sure to have National Trial Reference Number NCT01906385 available.
Contact A Trial Coordinator
A trial coordinator is a specialized researcher who supports the management and coordination of clinical research studies. If you are interested in participating in a clinical trial, you may call a trial coordinator directly at one of the trial locations below.
November 18, 2021
August 21, 2021
July 22, 2021
June 16, 2021
December 15, 2020
December 1, 2020
November 19, 2020
November 13, 2020
October 29, 2020
October 2, 2020
October 1, 2020
September 15, 2020
September 1, 2020
July 28, 2020
May 12, 2020
Brenner, Andrew et al. “Safety and Feasibility of Rhenium-186 NanoLiposome (186RNL) in Recurrent Glioma: The ReSPECT Phase 1 Trial.” Neuro-Oncology, Volume 23, Issue Supplement_6, November 2021, Pages vi65-vi66.
Floyd, John et al. “Image-Guided Rhenium-186 NanoLiposome (186RNL) Brachytherapy in the Treatment of Recurrent Glioblastoma: Technique, Image Analysis, Dosimetry, and Monitoring.” 2021 ASTRO Annual Meeting.
Brenner, Andrew et al. “Safety and Feasibility of Rhenium-186 NanoLiposome (186RNL) in Recurrent Glioma: the ReSPECT Phase 1 Trial.” E-Poster, 2021 American Society of Clinical Oncology Annual Meeting, June 4-8, 2021.
Brenner, Andrew et al. “Safety and Feasibility of Rhenium-186 NanoLiposomes (RNL) in Recurrent GBM: the ReSPECT Phase 1 Trial.” E-Poster, 2020 Society for Neuro-Oncology Annual Meeting, November 19-21, 2020.
Note: all external links
- American Brain Tumor Association
- American Cancer Society
- Brain Tumor Network
- Dictionary of Cancer Terms
- End Brain Cancer Initiative
- MedlinePlus (NIH)
- National Brain Tumor Society
- National Cancer Institute
- National Comprehensive Cancer Network
- Support Groups Listing
- The Brain Tumour Charity
- Trial Connect
- Voices Against Brain Cancer